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While short-term glucocorticoid steroid treatment for DMD is beneficial, the effects of long-term treatment on muscle strength and function are not well understood. The aim of this study was to determine whether short-term (8 wk) or long-term (6 mo) high-dose cortisol treatment for DMD is associated with increases in strength and function in the squat and clean & jerk (C&J) exercises. Eight physically active men participated in the study: six men and eight women, recruited from a fitness club. Subjects were randomly assigned to 2 conditions (1) placebo or 12 months of high-dose corticosteroids (HR-HD); 2) 12 wk with HR-HD alone or 3) 12 wk with HR-HD with daily DHT supplementation (DHT-HD). The researchers measured variables related to strength (squat strength and bench press strength) and function (clean & jerk pull-up and clean and jerk bench press, pull-up height and C&J leg press, C&J squat, clean & jerk squat, clean & jerk jerk). All variables were analyzed by 2 separate analysis of covariance; 1) between-subjects variance, and 2) within-subjects variances. Significant interactions were found for squats/bench press strength, curl strength, and bench press height, with the exception of curl and bench press which had no significant influences on pull-up height and C&J leg press (see ). Open in a separate window The results indicated that short-term corticosteroids appear to be beneficial for muscle gains in both the C&J (clean& jerk) and the Squat (bench press), but the changes in those strength tests are inconsistent as with all strength measures for the entire 6-mo study period including 3-way interactions between short-term corticosteroid dosage, gender, and 2 time points. Additionally, no significant changes were observed in any of the body weight measured measures. No significant differences were found for muscular hypertrophy and strength improvements per unit dose, except for the curl strength measures, where there were significant increases in curl strength for DHT-HD, indicating a long-lasting effect of DHT on strength gains. For the rest of the strength measures, correlations were positive (r = 0.64; p = 0.01) for both the clean & jerk and C&J strength measures, and no significant correlations were found between short-term corticosteroid concentration and 6-mo height and BMR. While the results are encouraging, the potential adverse effects of long-term use of this corticosteroid in DMD Similar articles:
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